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Read the UCLA Depression Grand Challenge 2025 Year in Review

The UCLA Depression Grand Challenge’s 2025 Year in Review, was shared with newsletter subscribers by DGC Director Nelson Freimer, MD on Dec. 24, 2025. Freimer’s message celebrated ten years of the DGC’s mission to cut the burden of depression on human health and well-being in half by 2050, and overviewed updates on the following:

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Chart showing data collected from study participants over 52 weeks of enrollment, indicating ~4,000 enrolled at start and ~3,000 finishers.
First publication on DMHS posted on medRxiv, shares protocol details of landmark study

A preprint protocol article describing the design and implementation of the landmark Digital Mental Health Study was posted on medRxiv on Oct. 1, 2025 and has been submitted for publication in a peer-reviewed journal. Senior authors of this protocol article from UCLA include Nelson Freimer, MD, UCLA Depression Grand Challenge director and DMHS principal investigator; Michelle Craske, PhD, DGC co-director.

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Causes & Trajectories
Advancing the use of sensor-based digital health technologies for mental health research and clinical practice
DiMe-DGC collaboration releases Wellcome-funded report outlining recommendations to drive investment, direction in digital sensing for mental health

The Digital Health Measurement Collaborative Community (DATAcc) by the Digital Medicine Society (DiMe), in which Depression Grand Challenge team members participated, released a report on Feb. 4, 2025, detailing evidence-based, actionable recommendations to drive interest, investment, and direction for sensor-based digital health technology research and innovation.

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Causes & Trajectories
Chart listing obstacles of digital sensing in mental health research (expensive infrastructure, lack of community trust)
Paper based on 2023 Digital Sensing Workshop findings published in npj Digital Medicine, advocates for common standards for digital sensing in mental health research
The Perspective, “Advancing digital sensing in mental health research,” draws on insights, findings and related reports generated from the 2023 Workshop on Advancing Digital Sensing Tools for Mental Health, hosted by UCLA and sponsored by Wellcome, the National Institute of Mental Health and the DGC.
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UCLA Depression Grand Challenge logo
DGC joins DiMe-led consortium, submits proposal to Wellcome to conduct scoping project on use of digital sensing for mental health research
The UCLA Depression Grand Challenge collaborated with a consortium led by The Digital Health Measurement Collaborative Community (DATAcc) by the Digital Medicine Society (DiMe) to submit a proposal to Wellcome, a global charitable organization that funds discovery research, for the opportunity to conduct scoping research to assess how digital sensing technologies may be leveraged to detect and treat mental health conditions.
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